Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Orthologic is defined by weakening the axioms and rules of inference of the classical propositional calculus. The resulting Lindenbaum-Tarski quotient algebra is an orthoimplication algebra which generalizes the author's implication algebra. The associated order structure is a semi-orthomodular lattice. The theory of orthomodular lattices is obtained by adjoining a falsity symbol to the underlying orthologic or a least element to the orthoimplication algebra.

In Spandrels of Truth, Beall concisely presents and defends a modest, so-called dialetheic theory of transparent truth.

A good argument is one whose conclusions follow from its premises; its conclusions are consequences of its premises. But in what sense do conclusions follow from premises? What is it for a conclusion to be a consequence of premises? Those questions, in many respects, are at the heart of logic (as a philosophical discipline). Consider the following argument: 1. If we charge high fees for university, only the rich will enroll. We charge high fees for university. Therefore, only the rich (...) will enroll. There are many different things one can say about this argument, but many agree that if we do not equivocate (if the terms mean the same thing in the premises and the conclusion) then the argument is valid, that is, the conclusion follows deductively from the premises. This does not mean that the conclusion is true. Perhaps the premises are not true. However, if the premises are true, then the conclusion is also true, as a matter of logic. This entry is about the relation between premises and conclusions in valid arguments. (shrink)

The Liar paradox raises foundational questions about logic, language, and truth (and semantic notions in general). A simple Liar sentence like 'This sentence is false' appears to be both true and false if it is either true or false. For if the sentence is true, then what it says is the case; but what it says is that it is false, hence it must be false. On the other hand, if the statement is false, then it is true, since it (...) says (only) that it is false. -/- How, then, should we classify Liar sentences? Are they true or false? A natural suggestion would be that Liars are neither true nor false; that is, they fall into a category beyond truth and falsity. This solution might resolve the initial problem, but it beckons the Liar's revenge. A sentence that says of itself only that it is false or beyond truth and falsity will, in effect, bring back the initial problem. The Liar's revenge is a witness to the hydra-like nature of Liars: in dealing with one Liar you often bring about another. -/- JC Beall presents fourteen new essays and an extensive introduction, which examine the nature of the Liar paradox and its resistance to any attempt to solve it. Written by some of the world's leading experts in the field, the papers in this volume will be an important resource for those working in truth studies, philosophical logic, and philosophy of language, as well as those with an interest in formal semantics and metaphysics. (shrink)

Extensively classroom-tested, Possibilities and Paradox provides an accessible and carefully structured introduction to modal and many-valued logic. The authors cover the basic formal frameworks, enlivening the discussion of these different systems of logic by considering their philosophical motivations and implications. Easily accessible to students with no background in the subject, the text features innovative learning aids in each chapter, including exercises that provide hands-on experience, examples that demonstrate the application of concepts, and guides to further reading.

Semantic and soritical paradoxes challenge entrenched, fundamental principles about language - principles about truth, denotation, quantification, and, among others, 'tolerance'. Study of the paradoxes helps us determine which logical principles are correct. So it is that they serve not only as a topic of philosophical inquiry but also as a constraint on such inquiry: they often dictate the semantic and logical limits of discourse in general. Sixteen specially written essays by leading figures in the field offer new thoughts and arguments (...) about the paradoxes. (shrink)

Semantic and soritical paradoxes challenge entrenched, fundamental principles about language - principles about truth, denotation, quantification, and, among others, 'tolerance'. Study of the paradoxes helps us determine which logical principles are correct. So it is that they serve not only as a topic of philosophical inquiry but also as a constraint on such inquiry: they often dictate the semantic and logical limits of discourse in general. Sixteen specially written essays by leading figures in the field offer new thoughts and arguments (...) about the paradoxes. (shrink)

We are pluralists about logical consequence [1]. We hold that there is more than one sense in which arguments may be deductively valid, that these senses are equally good, and equally deserving of the name deductive validity. Our pluralism starts with our analysis of consequence. This analysis of consequence is not idiosyncratic. We agree with Richard Jeffrey, and with many other philosophers of logic about how logical consequence is to be defined. To quote Jeffrey.

The Liar paradox raises foundational questions about logic, language, and truth. A simple Liar sentence like 'This sentence is false' appears to be both true and false if it is either true or false. For if the sentence is true, then what it says is the case; but what it says is that it is false, hence it must be false. On the other hand, if the statement is false, then it is true, since it says that it is false.How, (...) then, should we classify Liar sentences? Are they true or false? A natural suggestion would be that Liars are neither true nor false; that is, they fall into a category beyond truth and falsity. This solution might resolve the initial problem, but it beckons the Liar's revenge. A sentence that says of itself only that it is false or beyond truth and falsity will, in effect, bring back the initial problem. The Liar's revenge is a witness to the hydra-like nature of Liars: in dealing with one Liar you often bring about another.JC Beall presents fourteen new essays and an extensive introduction, which examine the nature of the Liar paradox and its resistance to any attempt to solve it. Written by some of the world's leading experts in the field, the papers in this volume will be an important resource for those working in truth studies, philosophical logic, and philosophy of language, as well as those with an interest in formal semantics and metaphysics. (shrink)

In this volume of fourteen original essays, a distinguished team of contributors explore the extent to which, if at all, deflationism can accommodate paradox.

The guiding idea of this work is that classical diffusion theory, being nonrelativistic, should be associated with nonrelativistic quantum mechanics. A study of classical diffusion leads to a generalization which should correspond to the relativistic domain. Actually, with a convenient choice of the basic constants, one sees the relativistic features (Lorentz contraction and covariant diffusion equation) emerge in the generalized process. This leads first to a derivation of the nonrelativistic and relativistic wave equations (and to a model of the Dirac (...) fluid); then to a better understanding of several relativistic aspects of quantum mechanics (spin connection with relativity and link of relativity with nonlocalization). No quantum mechanical forces are postulated: they arise as pseudo-forces in the course of the calculations. The physical significance of the stochastic model is examined and shown to give a pictorial description only in certain ideal situations, but to remove several conceptual difficulties. Remarks are presented on the role of idealization in microphysics. (shrink)

The stochastic approach worked out in earlier papers is applied to the Dirac fluid. It gives a model of the Schrödinger zitterbewegung, from which, by the spinor-vector correspondence, a model of the plane monochromatic wave in the rest frame is derived. The relation of the scheme with quantization is found to have the same character as in the previous papers. The link of spin with relativity is explained.

The stochastic scheme proposed in a previous paper as subjacent to quantum mechanics is analyzed in the light of the difficulties and criticisms encountered by similar attempts. It is shown that the limitation of the domain where the theory is valid gives a reply to the criticisms, but restricts its practical usefulness to the description of basic features. A stochastic approach of the hadron mass spectrum, allowing the scheme to emerge in the domain of experimental verification (to be worked out (...) in a later paper) is outlined. The model is found not to be in disagreement with Bell's argument opposed to hidden variables; a same origin is suggested for the difficulties encountered in both domains. The views proposed are compared with the Copenhagen interpretation: common points and divergences are analyzed. (shrink)

In this paper the squared mass of the hadron is defined as a random variable, whose average is the measured quantity. This leads to a mass formula, of a unique type for mesons and baryons, with a general law for the spin variation of the coefficients. The central squared masses form an overall geometrical scheme; in the baryon case it contains trajectories which are a fine structure of the Regge trajectories. For the accurately measured masses the difference between the computed (...) and experimental value lies within 5 MeV for mesons and baryons. The geometrical scheme will be the basis for the computation of the decay rates, to be developed in the next paper. (shrink)

In a previous paper a stochastic foundation was proposed for microphysics: the nonrelativistic and relativistic domains were shown to be connected with two different approximations of diffusion theory; the relativistic features (Lorentz contraction for the coordinate standard deviation, covariant diffusion equation) were not derived from the relativistic formalism introduced at the start, but emerged from diffusion theory itself. In the present paper these results are given a new presentation, which aims at elucidating not the foundations of quantum mechanics, but those (...) of relativity. This leads to a discussion of points still controversial in the interpretation of relativity. In particular two problems appear in a new light: the character of time and length alterations, and the privileged role of the velocityc. Besides, the question of a possible limitation of relativity (and more generally of the laws of mechanics) in the domain of particle substructure is raised and supported by exemples drawn from the hydrodynamical model of a spinned particle. Suggestions are presented for the possibility of a deeper conceptual unification of special and general relativity. (shrink)

Semantic and soritical paradoxes challenge entrenched, fundamental principles about language - principles about truth, denotation, quantification, and, among others, 'tolerance'. Study of the paradoxes helps us determine which logical principles are correct. So it is that they serve not only as a topic of philosophical inquiry but also as a constraint on such inquiry: they often dictate the semantic and logical limits of discourse in general. Sixteen specially written essays by leading figures in the field offer new thoughts and arguments (...) about the paradoxes. (shrink)

The two purposes of this essay. The general philosophical problem with most versions of social libertarianism and how this essay will proceed. The specific problem with liberty explained by a thought-experiment. The positive and abstract theory of interpersonal liberty-in-itself as ‘the absence of interpersonal initiated constraints on want-satisfaction’, for short ‘no initiated impositions’. The individualistic liberty-maximisation theory solves the problems of clashes, defences, and rectifications without entailing interpersonal utility comparisons or libertarian consequentialism. The practical implications of instantiating liberty: three rules (...) of liberty-in-practice, 1) initial ultimate control of one’s body, 2) initial ultimate control of one’s used resources, 3) consensual interpersonal interactions and resource transfers. These rules are economically efficient and maximise general want-satisfaction. Private property and legal remedies are additional practical institutional aspects, but to which ‘initiated impositions’ then apply prima facie. Libertarian law is often mistaken for complete libertarianism. Moral explanations are a separate issue. The three main moral theories imply libertarianism, but it can be morally posited independently of them. Critical rationalism and its application. No empirical or argumentative support for theories. An important ambiguity with ‘justification’. How the epistemology applies to the theory of liberty and its application but remains separable in principle. Conclusion: there are further published explanations but this should be enough to generate useful criticism. Appendix replying to some typical comments. (shrink)

In the late nineteenth century and the early decades of the twentieth thematic resemblances to the Roman elegists in Paulus Silentiarius were explained as the result of the poets' reliance on a common Hellenistic source – usually this was identified as the so-called ‘subjective Alexandrian love elegy’ – and this represented a departure from the views of earlier scholars such as Hertzberg and Postgate, who had maintained that Paulus knew and imitated the elegists. In recent years the pendulum has swung (...) back , and the prevailing opinion seems to be that the Roman elegists were known to Paulus. This is the view of, for instance, Giovanni Viansino in his edition of Paulus, of Elmar Schulz-Vanheyden in his important work on Propertius' relationship to Greek epigram, and of Hermann Beckby in his edition of the Greek Anthology. Recently, too, Gordon Williams has put forward a very strong case for earlier epigrammatists like Antipater and Crinagoras imitating the Augustan poets. (shrink)

The aim of this paper is to show the relationship between the normative outlook and political philoso- phy of traditional societies on the one hand, and the crises of governance and leadership in contemporary African Societies, particularly subSaharan states, on the other. Although there are quite some differences in the quality of leadership and governance among sub-Saharan African states because of the different political and economic circumstances, this part of the globe taken as a whole remains underdeveloped in terms of (...) having the will to institute and maintain stable polities with responsive, responsible and efficient governance. (shrink)

This paper examines the role of ideology in the emergence of the empirical sciences and the evolution of philosophy. It argues that the orientation of the religious ideology, Christianity, at the epistemological and ontological levels was very instrumental in the emergence of the empirical sciences in the area dominated by the culture of the Western (Latin) church. This claim is demonstrated by an analysis of the theoretical and methodological orientation of pre-Christian Europe, the epistemological and other philo- sophical values sponsored (...) by Christianity, as well as a comparative analysis of other cultural regions where such philosophical values did not exist. The paper then explores the evolution of philosophy after the emergence of the empirical sciences. It points out that the progress of philosophy along rational lines and the generation of knowledge thereof is not equivalent to embracing the method of the empirical sciences (scientism), but rather is a rediscovery of the rational attitude bearing in mind the context in which it has to operate. (shrink)